Molly Pitcher Highway, South Antrim Way, North Antrim Way, South Main Street, South Second Street, Philadelphia Avenue, Edgar Avenue, West King Street, East King Street, Ritner Highway, West High Street, North Hanover Street, Harrisburg Pike, Carlisle Pike, North 32nd Street, Cumberland Boulevard, Camp Hill Bypass, Walnut Street, North Front Street, South Enola Road, North Enola Road, South State Road, State Road, Susquehanna Trail, Selinsgrove Bypass, Water Street, Front Street, Point Township Drive, Northumberland Street, Montour Boulevard, West Main Street, East Street, Columbia Boulevard, West Front Street, East Front Street, Salem Boulevard, North Main Street, Chestnut Street, East Poplar Street, East Main Street, Wyoming Avenue, Fort Jenkins Bridge, Kennedy Boulevard, William Street, South Township Boulevard, Pittston Bypass, Pittston Avenue, Main Street, Birney Avenue, Sanders Street, Cedar Avenue, Jefferson Avenue, Mulberry Street, North Scranton Expressway, Northern Boulevard, State Street, Lackawanna Trail

Southern Terminus:
Maryland-Pennsylvania state line
Northern Terminus:
Pennsylvania-New York state line
227.93 miles
Franklin, Cumberland, Perry, Juniata, Snyder, Northumberland, Columbia, Luzerne, Lackawanna, Wyoming, Susquehanna

US 11 is a major north/south route running diagonally from New Orleans, Louisiana, to the Canadian border in Rouses Point, New York. It enters Pennsylvania from Maryland just north of Hagerstown and runs northeast, next to I-81, to Harrisburg, where it merges with the Capital Beltway (PA 581). The two routes are multiplexed for a couple of exits, and then US 11 splits off and joins US 15. US 11 and US 15 runs north multiplexed along the Susquehanna River. Just south of Northumberland, the two routes split. US 11 continues northeast along the river, passing just west of Wilkes-Barre and eventually reaching Scranton. US 11 passes through the central area of the city before becoming the North Scranton Expressway. The expressway runs north for a couple of miles before ending at an interchange with I-81. US 11 becomes Northern Boulevard, which runs parallel to I-81. In Clarks Summit, the Northeast Extension of the Pennsylvania Turnpike (I-476) has its northern terminus at Northern Boulevard, and US 6 joins US 11 at this point. Heading out of Clarks Summit, Northern Boulevard becomes Lackawanna Trail. In Factoryville, US 6 splits off. US 11 continues north along Lackawanna Trail to the New York border.

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