- Southern Terminus:
- Connecticut Turnpike (I-95) in East Lyme
- Northern Terminus:
- Connecticut-Massachusetts state line
- 54.69 miles
- New London, Windham
A few miles east of the Connecticut River, the Connecticut Turnpike leaves I-95 and runs north as I-395, while I-95 continues east toward Rhode Island. At exit 35 in Killingly, the Connecticut Turnpike splits off from I-395 to run east to US 6 at the Rhode Island border as the unsigned SR 695. I-395 continues north into Massachusetts.
Originally I-395 used an exit numbering scheme that continued the numbers from I-95, since both are considered to be part of the Connecticut Turnpike. It had the only three-digit exit numbers in the state. The exits have since been renumbered based on a milepost system, making it one of the few roads in the state to use such a system at this point.