- Southern Terminus:
- US 52 in Bluewell
- Northern Terminus:
- Mountaineer Highway (WV 7) in New Martinsville
- Mercer, Summers, Greenbrier, Nicholas, Webster, Upshur, Barbour, Harrison, Wetzel
WV 20 is a north/south route running near the center of West Virginia. It begins in Bluewell near the border with Virginia and runs north through rural surroundings to Buckhannon and eventually reaches Clarksburg. There, it is multiplexed with US 19 to the north for a few miles before splitting off to the northwest to end in New Martinsville near the border with Ohio. It is one of the longest routes in the state.