Bedford Valley Road, South Main Street, North Main Street, Appalachian Thruway, Cliff Avenue, Appalachian Parkway, German Street, Front Street, James Monroe Avenue, Main Street

Direction:
North/South
Southern Terminus:
Maryland-Pennsylvania state line
Northern Terminus:
Southern Tier Expressway (I-86/NY 17) at the Pennsylvania-New York state line
Distance:
131.12 miles
Counties:
Bedford, Blair, Centre, Clinton, Lycoming, Sullivan, Bradford
Signed:
Yes

US 220 is a north/south route extending from Rockingham, North Carolina to South Waverly, Pennsylvania, along the border with New York. It enters Pennsylvania from Maryland a couple of miles north of the National Freeway (I-68). The southernmost section in the state is a two-lane road called Bedford Valley Road. In Bedford, it widens to become an expressway and has an interchange with the Pennsylvania Turnpike (I-76). I-99 begins at this point and is multiplexed with US 220 for its entire length, ending at I-80. US 220 follows I-80 east for a few exits. Then, it splits off and runs north and east to Williamsport, where it has an interchange with US 15. I-180 begins at this point. Both US 15 and US 220 are multiplexed with I-180 at first. This is a wrong-way multiplex; US 15 south and US 220 north follow I-180 east. US 15 splits off to the south first, while US 220 remains multiplexed for a little longer. Then, it splits off and runs north and east through the mountains to the state line. It ends at the Southern Tier Expressway (I-86/NY 17), which dips south of the border into Pennsylvania right near the northern terminus of US 220.

There are plans to upgrade the section of US 220 between I-80 and US 15 to interstate standards. Once this is done, I-99 will be extended north to New York following I-80, US 220, and US 15.

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