West Lake Road, East Lake Road, Lake Shore Drive West, Lake Shore Drive East, Lake Road, Howard Street, Main Road, Erie Road, Lakeshore Road, Hamburg Turnpike, Buffalo Skyway, Church Street, South Division Street, Ellicott Street, Pearl Street, Main Street, Caledonia-Leroy Road, State Street, Caledonia Avon Road, East Avon Road, East Avon Lima Road, Buffalo Road, Hamilton Street, Waterloo Geneva Road, Lake Front Drive, Fall Street, Cayuga Street, Auburn Road, Clark Street Road, Grant Avenue, West Main Street, East Main Street, West Genesee Turnpike, West Genesee Street, Erie Boulevard East, East Genesee Street, Genesee Turnpike, Genesee Street, Seneca Turnpike, Seneca Avenue, North-South Arterial Highway, Leland Avenue, Herkimer Road, West State Street, East State Street, Mohawk Turnpike, West Grand Street, East Grand Street, Cranes Hollow Road, Amsterdam Road, Mohawk Avenue, Western Gateway Bridge, Central Avenue, Washington Avenue, Broadway

Direction:
East/West
Western Terminus:
East Lake Road (PA 5) at the Pennsylvania-New York state line
Eastern Terminus:
I-787 in Albany
Distance:
370.80 miles
Counties:
Chautauqua, Erie, Genesee, Livingston, Ontario, Seneca, Cayuga, Onondaga, Madison, Oneida, Herkimer, Montgomery, Schenectady, Albany
Signed:
Yes

NY 5 is a major east/west route in Upstate New York, extending from Albany all the way to the Pennsylvania border, where it becomes PA 5. It serves as a local and free alternative to the New York Thruway (I-90), which it is fairly close to throughout its length. It follows the local streets for most of its length, although there is an expressway section in Buffalo called the Buffalo Skyway. In Utica, it is multiplexed with NY 8 and NY 12 as the North-South Arterial Highway, which has a mixture of grade-separated interchanges and traffic lights. At the end of the arterial, it is multiplexed with I-790 for its entire length. There is also a long multiplex with US 20 for a good part of the distance between Rochester and Syracuse.

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