- Southern Terminus:
- NY 52 in Hopewell Junction
- Northern Terminus:
- Maple Street (US 44/NY 55) in Poughkeepsie
- 13.86 miles
NY 376 is a north/south route in the southern half of Dutchess County. It extends from NY 52 in Hopewell Junction to Maple Street (US 44/NY 55) in Poughkeepsie. The entire length is a two-lane road. Most of it is undivided, although there is a divided section with traffic circles in Poughkeepsie near the campus of Vassar College.