- Southern Terminus:
- Oriskany Boulevard (NY 69) in Whitesboro
- Northern Terminus:
- NY 365 in Stittville
- 7.49 miles
NY 291 is a north/south route extending from Whitesboro, just northwest of Utica, to Stittville. It begins at Oriskany Boulevard (NY 69) just south of the Utica-Rome Expressway (NY 49) and ends at NY 365. The entire length is a two-lane undivided road. It has no name and is known solely by its number.