- Southern Terminus:
- Brooklyn-Queens Expressway (I-278) and Humboldt Street in Brooklyn
- Northern Terminus:
- Pulaski Bridge in Brooklyn
McGuinness Boulevard is a major roadway in the Greenpoint section of Brooklyn. It is also the southern approach to the Pulaski Bridge. It extends south from the bridge for a little over a mile to the Brooklyn-Queens Expressway (I-278), where it ends and turns into a local southbound one-way street called Humboldt Street. The entire length is a four-lane divided boulevard.