- Western Terminus:
- NY 308 in Rhinebeck
- Eastern Terminus:
- Milan Hollow Road (CR 15) in Rhinebeck
- 3.76 miles
CR 52 is a short east/west route in Rhinebeck. It begins at NY 308 as Salisbury Turnpike and runs east. After about a mile, Salisbury Turnpike splits off to become a local street. CR 52 continues east as Round Lake Road to end at Milan Hollow Road (CR 15). The entire length is a two-lane undivided road.