Welcome to Maryland! Jefferson Pike widens to become a four-lane divided highway upon entering the state. There is a flasher at Valley Road and Keep Tryst Road.

Photos taken April 2017.

There is an exit for Rohrersville Road (MD 67).

Photos taken April 2017.

Welcome to Frederick County! There is an exit for Jefferson Pike (MD 180) and Knoxville Road (MD 478). Jefferson Pike splits off here to become a surface road. US 340 continues straight ahead as Jefferson National Pike.

Photos taken April 2017.

There is an exit for Burkittsville Road (MD 17).

Photos taken April 2017.