- Western Terminus:
- Shore Highway (MD 404) in Denton
- Eastern Terminus:
- Greensboro Road (MD 313) in Greensboro
- 9.08 miles
MD 480 is a short diagonal route on the Eastern Shore of Maryland. It begins at Shore Highway (MD 404) in Denton and extends northeast through Ridgely to end at Greensboro Road (MD 313) in Greensboro. For most of its length, it is known as Ridgely Road. In Greensboro, it changes names to become Main Street. The entire length is a two-lane undivided road.