- Western Terminus:
- George Street (MD 537) in Chesapeake City
- Eastern Terminus:
- Bethel Church Road (DE 286) at the Maryland-Delaware state line
- 2.09 miles
MD 286 is a short east/west route running just south of the Chesapeake and Delaware Canal is Chesapeake City. It begins at George Street (MD 587), just east of the Chesapeake City Bridge, and runs east to the border with Delaware, where it becomes Bethel Church Road (DE 286). The entire length is a two-lane undivided road.