Lancaster Street, West Boylston Street, Main Street, Water Street, High Street, High Street Extension, Still River Road, Ayer Road, Littleton Road, King Street, Chelmsford Street, Appleton Street, Church Street, Andover Street, Nesmith Street, VFW Highway, Merrimack Avenue, Lowell Boulevard, Lowell Street, Haverhill Street, Jackson Street, Swan Street, East Street, Merrimack Street, River Street, Emerson Street, White Street, Kenoza Avenue, Amesbury Road, West Main Street, East Main Street, Haverhill Road, Macy Street, Elm Street

Direction:

East/West

Western Terminus:

Sterling Street (MA 12) in West Boylston

Eastern Terminus:

Bridge Road (US 1) in Salisbury

Distance:

69.92 miles

Counties:

Worcester, Middlesex, Essex

Signed:

Yes

MA 110 is a diagonal route extending from West Boylston just outside of Worcester to Salisbury near the border with New Hampshire. It begins at Sterling Street (MA 12) just north of where MA 140 splits off from it. It runs northeast to Harvard. From there, it follows MA 111 to the north and then MA 2A to the east. After an interchange with I-495, the two routes split. MA 110 runs parallel to I-495 to Chelmsford, where it crosses the highway again. It continues northeast through Lowell, Lawrence, and Haverhill. There are partial interchanges with I-495 and I-95 just south of where the two highways merge together. Shortly thereafter, MA 110 ends at Bridge Road (US 1).