- Southern Terminus:
- Maryland-Delaware state line
- Northern Terminus:
- Pulaski Highway (US 40) and South College Avenue (DE 896) in Newark
- 14.93 miles
- New Castle
US 301 is a north/south route extending from Sarasota, Florida, to Newark, Delaware. The section in Delaware is relatively short. It enters the state from Maryland south of Middletown. The first section is a two-lane undivided road called Middletown Warwick Road. Warwick Road (DE 299) joins US 301 just north of the state line. After a short distance, Middletown Warwick Road widens to become a four-lane divided highway. DE 299 splits off to run east as Main Street. North of Middletown, North Broad Street (DE 71) merges with Middletown Warwick Road to form Summit Bridge Road. After another couple of miles, DE 896 joins US 301/DE 71 along Summit Bridge Road. The Summit Bridge carries Summit Bridge Road across the Chesapeake and Delaware Canal to Bear. On the other side, DE 71 splits off to run east as Red Lion Road. Summit Bridge Road continues north to Pulaski Highway (US 40) in Newark, where US 301 ends. DE 896 continues north as South College Avenue.
Construction work is in progress to build a new toll highway that will extend from US 301 at the border with Maryland to the DE 1 toll highway just south of the Chesapeake and Delaware Canal. Once the new toll highway is open, it will be designated US 301, and the current alignment will be decommissioned.