- Southern Terminus:
- Walnut Street (Business US 13) in Wilmington
- Northern Terminus:
- Delaware-Pennsylvania state line
- 7.87 miles
- New Castle
DE 52 is a continuation of PA 52 south into Delaware. It begins at Walnut Street (Business US 13) in Wilmington as a pair of parallel one-way streets. Northbound traffic follows Twelfth Street, while southbound traffic follows Eleventh Street. Just before crossing I-95, the northbound and southbound lanes come together as Delaware Avenue. On the other side of the highway, Delaware Avenue splits off to become a local street, and DE 52 continues as Pennsylvania Avenue. Heading out of Wilmington, Pennsylvania Avenue becomes Kennett Pike. It continues north through the suburbs to the border with Pennsylvania, where it becomes PA 52.